Cannabis for systemic sclerosis / scleroderma

Reviewed by Gavin Moreland, MD | Written by Dipak Hemraj | Last updated on Apr 29, 2026
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Systemic sclerosis (scleroderma) is an autoimmune condition where the immune system attacks the skin and internal organs, and the scar tissue that covers the wounds grows harder and thicker than normal, interfering with organ function. Systemic sclerosis is associated with other autoimmune conditions like Raynaud’s phenomenon (red, white and blue changes of the fingers that occur with cold exposure, sometimes leading to painful sores and ulcers).

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Cannabis could be useful for many different types of autoimmune disorder, and systemic sclerosis is no different in this regard. This is due to cannabinoids’ ability to inhibit inflammatory cytokine production, as well as their analgesic properties, but more clinical trials need to be done to confirm such properties in humans.

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Frequently asked questions

Is multiple sclerosis a qualifying condition for medical cannabis?

Yes — multiple sclerosis is one of the most commonly approved qualifying conditions for medical cannabis across the United States and internationally. It is included on the approved conditions list in virtually every medical cannabis state, reflecting strong evidence for cannabis in MS symptom management.

How does medical cannabis help people with MS?

Medical cannabis is particularly effective for several MS symptoms, including spasticity and muscle stiffness, neuropathic pain, bladder dysfunction, fatigue, and sleep disturbances. Nabiximols (Sativex), a cannabis-derived oral spray, is approved specifically for MS spasticity in many countries.

Does cannabis help with MS-related spasticity?

Yes — spasticity is one of the best-evidenced applications of medical cannabis in MS. Both THC and CBD contribute to muscle relaxation and reduced stiffness. Many patients who don't respond well to standard antispasticity medications (baclofen, tizanidine) find significant relief with cannabis.

Will cannabis affect my MS disease-modifying therapy (DMT)?

There are no known major interactions between cannabis and most MS DMTs. However, cannabis may interact with other medications in your regimen. Share your complete medication list with your Leafwell provider to ensure a safe and appropriate recommendation.

How do I start with medical cannabis if I have MS?

Start by booking an online consultation with a Leafwell provider. They'll review your MS history, current symptoms, and medications, then walk you through your options. If you qualify, you can have your recommendation the same day.

Animal Study

9

Clinical Trial

2

Double Blind Clinical Trial

1

Laboratory Study

3

Meta-analysis

10

Total studies

Cannabis for systemic sclerosis / scleroderma

25

Positive

23 studies

92%

Inconclusive

1 studies

4%

Negative

1 studies

4%

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