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Cannabis for Systemic Sclerosis / Scleroderma

Systemic sclerosis (scleroderma) is an autoimmune condition where the immune system attacks the skin and internal organs, and the scar tissue that covers the wounds grows harder and thicker than normal, interfering with organ function. Systemic sclerosis is associated with other autoimmune conditions like Raynaud’s phenomenon (red, white and blue changes of the fingers that occur with cold exposure, sometimes leading to painful sores and ulcers).

Cannabis could be useful for many different types of autoimmune disorder, and systemic sclerosis is no different in this regard. This is due to cannabinoids’ ability to inhibit inflammatory cytokine production, as well as their analgesic properties, but more clinical trials need to be done to confirm such properties in humans.

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Research Overview

Animal Study

9

Clinical Trial

2

Double Blind Clinical Trial

1

Laboratory Study

3

Meta-analysis

10

Total studies

Systemic Sclerosis / Scleroderma

25

Positive

23 studies

92%

Inconclusive

1 studies

4%

Negative

1 studies

4%

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