Nausea is the feeling of sickness and wanting to vomit, though nausea does not always lead to vomiting. Nausea and vomiting are not always harmful but are common signs or side effects of many health problems, treatments and medications.
Medical cannabis often contains several compounds with antiemetic (anti-nausea and anti-vomiting) properties. Cannabis has been found to be particularly useful for managing nausea associated with chemotherapy.
Get your medical marijuana card
Connect with a licensed physician online in minutes.
Larger purchase limits 
Access to higher potency strains 
Save up to 40% on product taxes 
Enhanced legal protection
Nausea causes
Nausea is more often a symptom of another underlying health problem than a condition in and of itself, although a condition called cyclic vomiting syndrome, or CVS, does exist. Nausea does not always lead to vomiting, but the causes and treatments are often the same.
Headaches and migraines can cause nausea, as can various drugs and medications. Many treatments or health problems can cause nausea and vomiting, including:
- Chemotherapy and cancer
- Fainting and dizziness
- Exposure to heat
- Stomach infections such as norovirus or food poisoning
- GI problems such as gastroesophageal reflux disease (GERD) or gastroparesis
- Low blood sugar
- Diabetes
- Motion sickness or any loss of balance resulting from disturbance of the inner ear
- Depression
- Anxiety
- Alcohol use
- Pregnancy and hyperemesis gravidarum (HG)
- Seeing, smelling and/or tasting something particularly vile
There are many other triggers.
Dopamine (D2), serotonin (5HT3), neurokinin (NK1), antihistamine, acetylcholine, and TRPV1 (vanilloid) receptors all play a role in causing the sensation of nausea. The group of receptors responsible for nausea and vomiting are often referred to as the “chemoreceptor trigger zone.”
Nausea is a qualifying condition in most states.
See if you qualify →
- Get approved in minutes
- Same-day appointments available
- Money back guarantee
Nausea symptoms & health effects
Nausea is an unpleasant feeling that can reduce a person’s quality of life (QoL). Signs, symptoms, and effects of nausea include:
- Feeling like you are about to vomit
- Vomiting
- Lack of appetite
- Stomach ache
- Feeling like you are overheating
- Profuse sweating, including cold sweats
- Shivering
- Retching (rhythmic labored spasmodic movements of the diaphragm & abdominal muscles)
- Uneasy feeling in your chest, upper abdomen, or back of your throat
Nausea diagnosis
If you are feeling persistently nauseous, then your physician will typically perform a physical exam, inquire about your symptoms and medical history, and look for signs of dehydration. Your doctor may also order tests and refer you to a specialist in order to determine any underlying conditions that could be causing nausea and vomiting.
Nausea prognosis
In most instances, nausea will go away on its own. Persistent nausea, however, may be the sign of a more serious underlying condition, and can severely impact a person’s quality of life. On its own, nausea or vomiting will not necessarily reduce life expectancy, but the condition it is associated with may do so.
If you are feeling nauseous and vomiting for more than three days or due to a head injury (no matter how light), then it is wise to see your doctor.
Nausea treatments
Treatment depends on the cause of the nausea. Generally, medications like antacids and antiemetics may be prescribed for nausea and vomiting.
First-line treatments
Typical first line treatments and medications include:
- Eating bland foods such as bread, potatoes, and rice to prevent indigestion and heartburn
- Bismuth subsalicylate (Pepto-Bismol, BisBacter), which is an antacid elixir medication used to treat temporary discomforts of the stomach and gastrointestinal tract
- Antihistamines, e.g. cinnarizine, cyclizine, promethazine hydrochloride, promethazine teoclate)
Nausea is a qualifying condition in most states.
See if you qualify →
- Get approved in minutes
- Same-day appointments available
- Money back guarantee
Other treatments
Should first-line treatments not work, other medications may be prescribed. These include:
- 5-HT3 receptor antagonists that block serotonin receptors, e.g., dolasetron (Anzemet) and granisetron (Kytril, Sancuso): These are usually prescribed for post-operative and cytotoxic drug nausea and vomiting.
- Dopamine antagonists, which block dopamine receptors on the brain stem, e.g., domperidone (Motilium) and olanzapine (Zyprexa). These are usually prescribed for nausea and vomiting associated with chemotherapy, radiation sickness, opioids, cytotoxic drugs, and general anesthetics.
- NK1 receptor antagonists such as aprepitant (Emend) and rolapitant (Varubi).
- The antidepressant mirtazapine (Remeron), which is also an antihistamine.
- Synthetic cannabinoids like dronabinol, levonantradol, and nabilone, which are structurally similar to delta-9-THC (but more potent), may be prescribed for managing nausea and vomiting associated with chemotherapy.
Adjunctive therapy & alternative treatments
Non-medical interventions for less chronic or severe nausea and vomiting include fresh air, sipping on cold drinks, and healthy, well-planned meals at fixed times of the day. Those who have food intolerances may need a change in diet.
Ginger, cloves, peppermint, chamomile, meadowsweet, and Devil’s Claw are common herbal remedies.
Cannabis for nausea
Antiemetics are generally well-tolerated, but they can have side effects such as constipation or diarrhea, headache, fatigue, malaise, dizziness, light-headedness, blurred vision, dry mouth, or photosensitivity. Some people may find some classes of antiemetics to be intolerable or ineffective.
Medical cannabis could be helpful in reducing or replacing the need for antiemetic medications, or as an effective alternative in the case of treatment resistance. Many find plant-derived cannabinoids (phytocannabinoids), such as a mixture of tetrahydrocannabinol (THC) and cannabidiol (CBD), more tolerable compared to synthetic ones like dronabinol and nabilone.
Cannabis also contains several compounds that have antiemetic properties, including THC, CBD,, and cannabichromene (CBC). THC, CBD, and CBC exert their antiemetic properties via interaction with cannabinoid receptor 1 (CB1) and serotonin receptor 5-HT3. Serotonin receptors are a common target for many antiemetic drugs.
Moreover, as phytocannabinoids and terpenes affect multiple receptors and have a wide range of effects, cannabis can be utilized as an analgesic, anti-inflammatory, antidepressant, and anticonvulsant as well as an antiemetic. This can help reduce the intake of other medications that may contribute or cause nausea and vomiting. The multi-therapeutic effects of cannabis are of particular use for cancer patients, who often have to manage pain, anxiety, insomnia, and appetite loss alongside nausea and vomiting.
It should be noted that overconsumption of THC and cannabigerol (CBG) may induce nausea and vomiting in some. According to animal studies, moderate-to-high doses of CBG may oppose the antiemetic effects of THC and CBD.
Additional information for patients
For those experiencing severe nausea and vomiting due to pregnancy, there are the charities like HER Foundation and March of Dimes.
Nausea is a qualifying condition in most states.
See if you qualify →
- Get approved in minutes
- Same-day appointments available
- Money back guarantee
Get your medical marijuana card
Connect with a licensed physician online in minutes.
Larger purchase limits Access to higher potency strains Save up to 40% on product taxes Enhanced legal protection
