The Right Cannabis for You
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Traumatic brain injuries (TBIs) and strokes are two different conditions, but both involve brain neurotoxicity and cell death, so treatment has similarities. Medical cannabis contains several phytocannabinoids (plant cannabinoids) with antioxidant, neuroprotective, and possible neurogenic properties.
A stroke is caused by a blockage of blood flow or rupture of an artery, leading to a lack of oxygen to brain cells and cell death. Common symptoms include sudden loss of speech, weakness, or paralysis of one side of the body. Every year, more than 795,000 people in the United States have a stroke. Smoking, cardiovascular diseases (CVDs), high cholesterol, high blood pressure, obesity, and diabetes are leading causes of stroke.
Traumatic brain injury (TBI) is a nondegenerative, non-congenital condition caused by external mechanical force to the head. This can lead to temporary or permanent impairment of physical, mental, and psychosocial functions. The CDC estimates that about 1.5 million Americans survive a TBI every year, with approximately 230,000 hospitalized and a mortality of 3% across all TBI severities. Those involved in professions and activities like athletics, construction, or working in the military or emergency services are at greater risk of suffering a TBI.
Those managing a TBI share nerve pain (neuropathy) and headaches. Post-traumatic stress disorder (PTSD) is a high-risk factor in patients with a TBI. TBIs can cause long-term physical, emotional, and cognitive problems.
Strokes and TBIs may increase glutamate neurotoxicity in the brain. Glutamate (glutamic acid) is an excitatory neurotransmitter abundant throughout the brain and nervous system, and it is necessary for various functions, including metabolism, learning, and memory. However, when glutamate builds up in the brain, it can lead to stroke.
Although most cases of TBI are mild and can be overcome with rest, ice packs, and over-the-counter drugs like acetaminophen (Tylenol, paracetamol) or ibuprofen (Advil, Nurofen), it is still essential to keep an eye on symptoms like worsening headaches, blurred vision, an increase in fatigue and extreme sleepiness.
More long-term and severe instances of TBI (as well as stroke, which could be seen as a subset of TBI to some extent) may require treatments such as:
Medications for TBI include:
Medications for strokes can include:
Lifestyle changes like exercise and following a flavonoid-rich diet may also be recommended.
There is mixed evidence on cannabis and whether or not it can cause strokes or help manage the aftereffects of suffering one. Several studies show a correlation between the use of cannabis (in particular, smoking it) and the likelihood of suffering a stroke, but, as they say, correlation does not necessarily mean causation. There are many factors to account for, including diet, tobacco smoking, and previous TBIs. Similarly, several studies show that cannabinoids like cannabidiol (CBD) and cannabigerol (CBG) have neuroprotective effects that could help treat acute brain damage. The roots of the cannabis plant also contain a type of phytosterol that may help lower cholesterol, called beta-sitosterol.
There is also a not-insignificant amount of scientific research into the use of cannabinoids to treat TBIs and chronic traumatic encephalopathy (CTE, previously known as dementia pugilistica or “punch-drunk syndrome”), as cannabinoids such as CBD may help protect the brain from neuroinflammation. Several cannabinoids, including tetrahydrocannabinol (THC) and CBD, may help prevent dangerous amounts of glutamate from forming, potentially preventing further brain damage. THC may do this by depressing glutamate transmission.
A product rich in terpenes may be ideal. Some may prefer CBD-rich formulations, others THC-rich ones. Cannabinoids like CBD, CBG, and CBC may be useful to promote neurogenesis.
“Pre-clinical TBI research suggests that cannabinoids have neuroprotective and psychotherapeutic properties. In contrast, recreational cannabis use has consistently shown to have detrimental effects. Our review identified a paucity of high-quality studies examining the beneficial and adverse effects of medical cannabis on TBI, with only a single phase III randomized control trial. However, observational studies demonstrate that TBI patients are using medical and recreational cannabis to treat their symptoms, highlighting inconsistencies between public policy, perception of potential efficacy, and the dearth of empirical evidence.”
Source: Hergert DC, Robertson-Benta C, Sicard V, Schwotzer D, Hutchison K, Covey DP, Quinn DK, Sadek JR, McDonald J, Mayer AR. “Use of Medical Cannabis to Treat Traumatic Brain Injury“. J Neurotrauma. 2021 Jul 15;38(14):1904-1917. doi: 10.1089/neu.2020.7148. Epub 2021 Jan 25. PMID: 33256496; PMCID: PMC8260892.
“…[T]he endocannabinoid system possesses potential drugable receptor and enzyme targets for the treatment of diverse TBI pathology. Yet, full characterization of TBI-induced changes in endocannabinoid ligands, enzymes, and receptor populations will be important to understand that role this system plays in TBI pathology. Promising classes of compounds, such as the plant-derived phytocannabinoids, synthetic cannabinoids, and endocannabinoids, as well as their non-cannabinoid receptor targets, such as TRPV1 receptors, represent important areas of basic research and potential therapeutic interest to treat TBI.”
Source: Schurman LD, Lichtman AH. “Endocannabinoids: A Promising Impact for Traumatic Brain Injury“. Front Pharmacol. 2017;8:69. Published 2017 Feb 17. doi:10.3389/fphar.2017.00069
There is good preclinical and anecdotal evidence that medical cannabis could be helpful in the management of symptoms associated with both strokes and traumatic brain injuries. However, more clinical trials are needed.
Please note: the information in this article does not constitute medical advice.
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