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Cannabis for Cannabis and its Adverse Effects, Cannabis Dependence and Cannabinoid Hyperemesis Syndrome (CHS)

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Last updated on Oct 7, 2024

Created on Jan 4, 2022

Cannabis is relatively safe, and there has been no instance of a death via overdose of natural cannabis alone. However, this doesn’t mean there aren’t some things to be concerned about, just as you should be concerned about with any other medication. These include side-effects such as:

  • feeling drowsy, tired or lethargic
  • feeling faint, nauseous or sick (also a treatment for such problems)
  • having problems with memory or concentrating
  • experiencing mild hallucinations
  • feeling confused, anxious or paranoid (also a treatment for anxiety)

Other concerns include cannabis clashing with other medications, in particular opioids, sedatives like benzodiazepines, antidepressants and blood thinners such as warfarin or aspirin.

As for cannabis dependence, although it is not physically addictive, approximately 9% of regular users can display cannabis use disorder, which includes compulsive cannabis use despite negative effects. However, most people who wish to stop using cannabis find little difficulty in doing so.

As for cannabinoid hyperemesis syndrome (CHS), it is a rare condition that occurs after several years of regular, heavy cannabis consumption. It causes compulsive, repeated and severe vomiting after using cannabis, which is only relieved after hot showers and stopping cannabis use. It is theorized that CHS occurs after long-term consumption of THC, where its antiemetic (nausea-stopping) effects stop and start having the opposite effect.

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Research Overview

Animal Study

41

Animal Study -

2

Clinical Meta-analysis

48

Clinical Trial

154

Double Blind Clinical Trial

105

Laboratory Study

15

Meta-analysis

436

Meta-analysis -

1

Total studies

Cannabis and its Adverse Effects, Cannabis Dependence and Cannabinoid Hyperemesis Syndrome (CHS)

802

Negative

423 studies

53%

Inconclusive

204 studies

25%

Positive

175 studies

22%

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