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Xeroderma Pigmentosum (XP)

Low to Moderate

Cannabis for Xeroderma Pigmentosum (XP)

Xeroderma pigmentosum is a genetic disorder where the skin has a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light. Severe sunburn, freckling in sun-exposed areas of the skin, and changes in skin pigmentation. Vitiligo, meanwhile, is a loss of melanin in the skin that can be caused by stress, and is often linked to autoimmune disorders as immune cells attack and destroy melanocytes. This can mean loss of pigmentation, and is a lifelong disorder.

There are few treatments available for loss of skin pigmentation. Moisturisers, sun cream and topical corticosteroids (which can cause loosening of the skin with long-term use) are common treatments. CBD may increase cutaneous aquaporin-3 production and exert a skin moisturizing effect.

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