Top 6 Hybrid Strains

This is perhaps one of the hardest marijuana strains to pick from. There are not only a vast number of hybrid strains, but there’s also the question of “What makes a strain a hybrid?”

Can indica- or Sativa-dominant strains be considered a hybrid? Or does it have to be an even 50:50 split? Or perhaps it’s all about the effects. If it is an “up” high followed by a stoned effect (or vice-versa), then it’s a hybrid? Or is it a mixture of the genetic and effect that makes a strain a hybrid?

To make matters worse, almost all non-landrace strains are hybrids, regardless of whether they are indica- or Sativa- dominant. This is because hybridization can keep plants vigorous & healthy, improve yields, save rare & unusual genetics, and make plants that might not otherwise grow in different climates. Moreover, even some landrace strains are hybrids due to new cannabis strains and cross-pollination in fields far and wide. The whole notion of a separation between indica and sativa is rough at best, as the two can share more in common than differences when looking at their actual genetic and chemical composition!

Well, whatever your opinion on this, here are some of the best hybrids around.

Top 6 Hybrid Strains

1. Cannatonic

This is the strain that helped kickstart the CBD revolution. When Resin Seeds released this strain, the world of marijuana changed dramatically. Without Cannatonic, there would be no ACDC, and the creators of Charlotte’s Web not have had proof that, yes, it’s possible to create a strain rich in CBD and low in THC.

cannatonic strain cannabis marijuana hybrid
Medical Jane has a review of the Cannatonic strain.

The work that has gone into making Cannatonic is amazing. Resin Seeds had to select from many strains to get what they and so many in the medical community wanted and needed. This included Congolese sativas, Pakistani kushes, the legendary strain Reina Madre and the fantastic NYC Diesel. Thankfully, they were successful and wisely released Cannatonic in standard seed form and feminized to allow for cross-breeding.

Cannatonic still tends to produce more CBD than most other CBD-rich strains, and the fact that it’s available in seed means that it doesn’t feel as “restricted” or “exclusive” as strains like Charlotte’s Web. Resin Seeds have also gone on to work with others in producing CBD-rich strains, and we’re sure they’ll carry on being at the cutting edge of marijuana science for some years to come.

This mostly CBD strain eventually found genetics in MK Ultra and G13 Haze. It’s known for producing a mellow, uplifting, and powerfully relaxing buzz. Cannatonic is often used to treat chronic pain, muscle spasms, anxiety, and migraines.

2. UK Cheese

uk cheese hybrid marijuana cannabis
An image of UK Cheese was posted on International Cannagraphic.

UK Cheese is a Skunk #1 phenotype that hails from the Chiltern Hills in England. This strain was developed by the Exodus Collective, who used to run amazing free parties during the early- to mid-90s. However, the Exodus Collective was more than just a group of marijuana-growing party fanatics – they also started and ran social housing projects, city farms, and drug rehabilitation programs.

Cheese was the Exodus Collective’s gift to the world, and in it, they created a type of cannabis perfect for the wet, temperate climes of the UK. Some clever Richard also decided to cross it with blueberry, to give us the excellent Blue Cheese.

For some, though, the original UK Cheese cannot be beaten. The flavor is funky, skunky, and a little fruity (and, of course, cheesy), and the effects can be energetic and euphoric before settling into an indica stone. Cheese is excellent for relaxing the muscles and pain relief and can provide Sativa effects without the “raciness.”

3. Skunk #1

Alongside Northern Lights #5, Skunk #1 helped usher in the homegrown revolution. A hybrid of Acapulco Gold, Colombian Gold, and Afghani varieties, the pedigree of the genetics speaks for itself. This hybrid tends to produce a high-energy buzz and kills stress. Skunk #1 is excellent for relieving stress, anxiety, depression, and fatigue. The smell and flavor are citrusy, earthy, and pungent.

The best thing about Skunk #1, though, is both its reliability and the various phenotypes that can be found within it. This makes Skunk #1 not only excellent for breeding and growing in all sorts of climates but also means that growers can find phenotypes on both the Sativa and indica ends of the spectrum.

It was a fantastic strain when the Sacred Seed Co. released it in the late 70s; a fantastic strain today, where Skunk #1 is still grown by both beginners and experts alike and is used in all sorts of breeding projects. Many brands, including Sensi Seeds, Dutch Passion, Flying Dutchman, Nirvana Seeds, and Royal Queen Seeds, have bred variations of this strain, like UK Cheese, Super Skunk, Island Sweet Skunk, and more…

4. Chemdawg ’91

chemdawg 91 cannabis marijuana
Chemdawg ’91, AllStrains

We could probably populate this list with all the strains from Chemdawg: Sour Diesel, OG Kush, Stardawg. The list could go on and on like the Energizer Bunny. However, we decided to go for the original: Chemdawg ’91. Also, this strain has one of the coolest stories around, as the strain was discovered in an ounce of high-quality pot bought at a Grateful Dead concert.

The origin of the name itself is rumored to go back to the name of the East Coast breeder that introduced it. Many speculate that it descends from a Thai landrace strain. It is also thought to be one of many strains bred from the original Chemdog strain, with 91 believed to be a reference to the year the strain came into existence.

Chemdawg ’91 is Sativa-leaning, but quite a few indica phenotypes are out there. The taste is very diesel-y, lemony, and piney, suggesting it could come from Thai, Nepali, and/or Skunk #1 ancestry, but the precise origins are shrouded in mystery. Medical marijuana users tend to take Chemdawg ’91 to help them feel happy, relaxed and uplifted, and it also makes a tremendous full-melt hash.

5. NYC Diesel

Bred by Soma Seeds, NYC Diesel is a Sativa-dominant hybrid bred by crossing Mexican and Afghani landrace strains. It provides cerebral effects that eventually settle into deep, full-bodied relaxation with no paranoia-inducing effects. NYC Diesel is great for socializing and tends to make a lot of people quite talkative!

NYC Diesel is great for stress, pain, inflammation, and fatigue. The CBD isn’t too high but high enough to take some of the edges off of the THC. There’s also lots of limonene and pinene, so the energetic effects are doubled with this strain! An excellent Sour Diesel cross if you can’t get a hold of the clone-only version.

It is likely the combination of flavor, relaxation, and euphoria that has won this strain five separate Cannabis Cup trophies in the early 2000s

6. Girl Scout Cookies (GSC)

One of the newest strains on this list and one of the most popular. In this case, the hype is merited. GSC is a fantastic strain with a great cannabinoid and terpene profile. Expect high THC, THCV, and CBG, some CBN, CBC, CBL, and small amounts of CBD.

The taste is sweet, with hints of mint, cherry, lemon, and, yes, slightly cookie-ish. Effects are happy, relaxed, uplifted, talkative, and creative and help relieve pain, nausea, headaches, and depression.

Another great thing about GSC is that it crosses OG Kush with an African strain that is almost dying out now: Durban Poison. This makes this strain extra special, as it mixes the phenotype range associated with OG Kush with the high THCV of Durban Poison.

This takes some of the edge and intensity off of the Durban Poison but retains its “up” qualities while at the same time giving the grower the potential to find an indica-leaning strain. The high THCV may also help those with diabetes and neuropathy.

Since this strain was created, it has given way to many variations, including Thin Mint and Platinum GSC. The original GSC strain has won numerous Cannabis Cup awards over the years.

marijuana cannabis strain durban poison
Durban Poison is an increasingly rare strain.

Other Popular Hybrid Strains to Consider

Six other hybrid strains of note: White Widow aka Black Widow; Gorilla Glue #1 & #4; OG Kush; Cinderella 99 aka C99 or Cindy 99; Bubblegum; AK-47.

Many strains could be called “hybrids” on this list (e.g., NL #5 x Haze, Jack Herer), with many of them being quite fantastic. However, we’d be here forever if we were to list them all.


Written by
Dipak Hemraj
Dipak Hemraj

Dipak Hemraj is a published author, grower, product maker, and Leafwell’s resident cannabis expert. From botany & horticulture to culture & economics, he wishes to help educate the public on why cannabis is medicine (or a “pharmacy in a plant”) and how it can be used to treat a plethora of health problems. Dipak wants to unlock the power of the plant, and see if there are specific cannabinoid-terpene-flavonoid profiles suitable for different conditions.