Explore A-Z conditions

Restless Leg Syndrome (RLS)

Moderate

Cannabis for Restless Leg Syndrome (RLS)

Restless leg syndrome (RLS) is where you get an overwhelming urge to move your legs, sometimes combined with strange, crawling or creeping sensations in the legs. It is often worse in the evening or at night, and can cause involuntary jerking at night during sleep. This is known as periodic limb movements in sleep (PLMS). RLS is also known as “Willis-Ekbom disease”. In the majority of cases, there is no known cause of RLS, but it can be caused by iron deficiency, kidney failure, pregnancy, conditions that cause involuntary movements (e.g. Parkinson’s), and drug & alcohol abuse or withdrawal.

RLS is caused by excessive dopamine production, and cannabis use is associated with reduced dopamine synthesis capacity. Cannabis may prevent excessive dopamine release and restore normal neural activity in the basal ganglia. Cannabis may also help treat any anxiety or insomnia associated with RLS. Cannabis could be an ideal replacement for dopamine agonists and anticonvulsants.

Get your medical marijuana card

Connect with a licensed physician online in minutes.


Meta-analysis

3

Total studies

Restless Leg Syndrome (RLS)

3

Positive

3 studies

100%

Do I qualify?

Select your state from the drop down and we’ll let you know.

Relevant studies

The information in our comprehensive A to Z encyclopedia comes from real scientific studies.

Uncover the detailed results of these studies and find out how effective medical marijuana is for dozens of conditions.