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Explore A-Z conditions
Systemic Sclerosis / Scleroderma
Moderate
Cannabis for Systemic Sclerosis / Scleroderma
Systemic sclerosis (scleroderma) is an autoimmune condition where the immune system attacks the skin and internal organs, and the scar tissue that covers the wounds grows harder and thicker than normal, interfering with organ function. Systemic sclerosis is associated with other autoimmune conditions like Raynaud’s phenomenon (red, white and blue changes of the fingers that occur with cold exposure, sometimes leading to painful sores and ulcers).
Cannabis could be useful for many different types of autoimmune disorder, and systemic sclerosis is no different in this regard. This is due to cannabinoids’ ability to inhibit inflammatory cytokine production, as well as their analgesic properties, but more clinical trials need to be done to confirm such properties in humans.
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Animal Study
9
Laboratory Study
2
Meta-analysis
8
Total studies
Systemic Sclerosis / Scleroderma
19
Positive
19 studies
100%
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Relevant studies
The information in our comprehensive A to Z encyclopedia comes from real scientific studies.
Uncover the detailed results of these studies and find out how effective medical marijuana is for dozens of conditions.
- Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system.
- Cannabinoid derivatives acting as dual PPARγ/CB2 agonists as therapeutic agents for systemic sclerosis
- Cannabinoids for the Treatment of Dermatologic Conditions
- Cannabinoids in dermatology: a scoping review.
- Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts.