Explore A-Z conditions

Psychosis

Low

Cannabis for Psychosis

Psychosis is when people lose some contact with reality, and can include hallucinations (seeing and/or hearing things that aren’t really there) and/or delusional thinking – thinking and believing things that are not actually true. Psychosis is often associated with schizophrenia and schizoaffective disorders. Those suffering from bipolar disorder may also suffer from psychosis, especially during their “manic” or “up” phases. Those who are prone to psychosis or have a family history of psychosis should avoid using THC.

However, cannabis contains hundreds of different compounds, all with different effects. Cannabidiol (CBD), which can dampen THC’s psychoactive effects to some extent, may actually be a potential treatment for psychosis. This could be due to CBD’s effect on dopamine receptors (a partial agonist), which could have a “moderating effect on the altered pattern of brain activity in the prefrontal, mediotemporal and striatal areas in people with psychosis.”

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Animal Study

5

Double Blind Human Trial

7

Human Trial

1

Laboratory Study

1

Meta-analysis

76

Total studies

Psychosis

90

Negative

33 studies

37%

Inconclusive

30 studies

33%

Positive

27 studies

30%

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