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Explore A-Z conditions
Huntington’s Disease (HD)
Moderate
Cannabis for Huntington’s Disease (HD)
Huntington’s disease is a condition that stops parts of the brain working properly over time. It is a genetic condition that is inherited from one’s parents. The condition usually starts in those between the ages of 30 and 50, and after 20 years can prove fatal.
Symptoms of Huntington’s disease can include:
- difficulty concentrating and memory lapses
- depression
- stumbling and clumsiness
- involuntary jerking or fidgety movements of the limbs and body
- mood swings and personality changes
- problems swallowing, speaking and breathing
- difficulty moving
Huntington’s disease results from the mutation of a single gene, which codes the protein known as “huntingtin”. This causes a degeneration of medium spiny neurons (MSNs) in the brain. CB1 receptors are highly expressed in MSNs. Targeting CB1 receptors for treatment could help protect the SMNs and prevent further degeneration due to cannabinoids’ neuroprotective effects.
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Animal Study
16
Clinical Meta-analysis
2
Double Blind Human Trial
2
Human Trial
2
Laboratory Study
7
Meta-analysis
36
Total studies
Huntington’s Disease (HD)
65
Positive
64 studies
98%
Inconclusive
1 studies
2%
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Relevant studies
The information in our comprehensive A to Z encyclopedia comes from real scientific studies.
Uncover the detailed results of these studies and find out how effective medical marijuana is for dozens of conditions.
- Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.
- Amyloid Proteotoxicity Initiates An Inflammatory Response Blocked By Cannabinoids
- A pilot study using nabilone for symptomatic treatment in Huntington's disease.
- A restricted population of CB1 cannabinoid receptors with neuroprotective activity.
- A systematic review of cannabidiol dosing in clinical populations