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Explore A-Z conditions
Fragile X Syndrome
Moderate
Cannabis for Fragile X Syndrome
Fragile X syndrome is a genetic disorder that can cause a range of developmental problems, most notably autism, learning disabilities and cognitive impairment. Affected individuals delayed development of speech and language by the age of 2. Males are more often affected than females.
Fragile X syndrome is associated with conditions like autism spectrum disorder (AUD), attention deficit disorder (ADD) and attention-deficit hyperactivity disorder (ADHD), and seizure disorders such as epilepsy. Fragile X syndrome is caused by a mutation in the FMR1 gene.
It is theorized that mutations in the FMR1 gene impairs neuronal excitability, meaning signals from the brain aren’t sent properly and/or are sent very slowly. Enhanced endocannabinoid signaling and anandamide production may help treat conditions associated with fragile X syndrome.
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Animal Study
8
Clinical Meta-analysis
1
Human Trial
1
Meta-analysis
2
Total studies
Fragile X Syndrome
12
Positive
12 studies
100%
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Relevant studies
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- A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome
- A systematic review of cannabidiol dosing in clinical populations
- Cannabidiol (CBD) Reduces Anxiety-Related Behavior in Mice via an FMRP-independent Mechanism
- Endocannabinoid-mediated Improvement on a Test of Aversive Memory in a Mouse Model of Fragile X Syndrome
- Enhanced Endocannabinoid Signaling Elevates Neuronal Excitability in Fragile X Syndrome