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Explore A-Z conditions
Down Syndrome
Moderate
Cannabis for Down Syndrome
Down syndrome is a condition where a child is born with an extra copy of their 21st chromosome. Effects can include delays in speech and development, attention problems, sleep difficulties, delays in cognition and stubbornness & tantrums.
There are 3 main types of down syndrome: trisomy 21, where there’s an extra copy of the 21st chromosome in every cell; mosaicism, where the extra chromosome copies only affect some cells; and translocation, where children have only an extra part of chromosome 21. Each year, about 6,000 babies are born with Down syndrome.
Researchers have found that people with Down syndrome have excessive endocannabinoid receptor activity in the hippocampus. Blocking off this excessive activity may be helpful in improving cognitive function in those with Down syndrome. Cannabis may also be able to help by protecting people from amyloid plaques, which has been linked to cognitive deficits in those with Alzheimer’s as well.
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Animal Study
3
Laboratory Study
1
Meta-analysis
1
Total studies
Down Syndrome
5
Positive
4 studies
80%
Negative
1 studies
20%
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Relevant studies
The information in our comprehensive A to Z encyclopedia comes from real scientific studies.
Uncover the detailed results of these studies and find out how effective medical marijuana is for dozens of conditions.
- Cannabinoid type-1 Receptor Blockade Restores Neurological Phenotypes in Two Models for Down Syndrome
- Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model
- Epidemiological overview of multidimensional chromosomal and genome toxicity of cannabis exposure in congenital anomalies and cancer development
- Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome.
- Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome