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Cardiac Fibrosis
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Cannabis for Cardiac Fibrosis
Fibrotic diseases cause annually more than 800,000 deaths worldwide, the majority of which are due to fibrosis of the heart or lungs. Fibrosis can be caused by aging or an injury, and it is characterized by the excess deposition of collagen, causing the heart valves to thicken and scar. This can cause further dysfunction of the heart.
The role and effect of cannabis and cannabinoids on heart function is not properly known, but there seems to be a complex effect, much of which is to do with the biphasic effects of cannabis. Much also depends on the method of ingestion. Cannabidiol (CBD) may attenuate “myocardial dysfunction, cardiac fibrosis, oxidative/nitrosative stress, inflammation, cell death, and interrelated signaling pathways.”
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Animal Study
1
Laboratory Study
1
Meta-analysis
1
Total studies
Cardiac Fibrosis
3
Positive
2 studies
67%
Negative
1 studies
33%
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Relevant studies
The information in our comprehensive A to Z encyclopedia comes from real scientific studies.
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- Activation Of Cannabinoid Receptor Type II By AM1241 Ameliorates Myocardial Fibrosis Via Nrf2-Mediated Inhibition Of TGF-β1/Smad3 Pathway In Myocardial Infarction Mice
- Cannabinoids, Inflammation, and Fibrosis
- Metabolites of Cannabis Induce Cardiac Toxicity and Morphological Alterations in Cardiac Myocytes