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<a href="https://leafwell.com/blog/terpenes/">Terpenes</a> play an essential role in the distinct bouquets of any cannabis strain, and chances are if you&rsquo;re a fan of Tangie or any other citrus-smelling strain/cultivar, you&rsquo;re familiar with valencene.
Valencene is <a href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID8047052" target="_blank" rel="noopener">a less common terpene found in cannabis</a> that produces the smell of sweet oranges, herbs, and fresh wood. It is so-named for its abundance in Valencia oranges and features a host of promising antioxidant and <a href="https://leafwell.com/blog/how-to-use-cannabis-to-manage-chronic-pain/">anti-inflammatory</a> properties, making it useful for treating conditions like <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409346/" target="_blank" rel="noopener">cancer</a>. Valencene is also a powerful insecticide often found in bug spray.
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<h6>Free Cannabinoid and Terpene Guide</h6>
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<h2 id="what-is-valencene">What Is Valencene?</h2>
Valencene is part of a group of larger, more complex terpenes called sesquiterpenes and is less common in cannabis than the similarly citrus-smelling <a href="https://leafwell.com/blog/limonene">limonene</a>. Valencene derives its name from the Valencia nature, the plant in which it most commonly occurs. The terpene features a sour taste with an herbal sweetness, more akin to oranges than lemon-like limonene.
Valencene can be found in many citrus fruits, such as grapefruit, tangerines, nectarines, and mangos. It appears in Chinese Bayberry, a valued medicinal herb, and is also the precursor molecule to <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/valencene" target="_blank" rel="noopener">nootkatone</a>, the terpene responsible for the distinct aroma of grapefruit.
Valencene is a potent insecticide and is often used in mosquito repellent products and other pest control and cleaning products. Valencene is a popular contributor to orange-scented personal care and beauty products and is also sometimes infused in olive oils and other food ingredients to provide an extra layer of flavor.
<img loading="lazy" class="size-full wp-image-32672 aligncenter" src="https://admin.leafwell.com/app/uploads/2022/01/5292576567_e398cfab5d_c.jpeg" alt="mixed citrus fruits in a white bowl" width="500" height="731" srcset="https://946256.smushcdn.com/2628119/app/uploads/2022/01/5292576567_e398cfab5d_c-410x600.jpeg?lossy=1&amp;strip=1&amp;webp=1 410w, https://946256.smushcdn.com/2628119/app/uploads/2022/01/5292576567_e398cfab5d_c.jpeg?lossy=1&amp;strip=1&amp;webp=1 500w" sizes="(max-width: 500px) 100vw, 500px">
<h2 id="health-benefits-and-uses">Health Benefits and Uses</h2>
Like its fellow citrus terpene limonene, valencene reportedly produces euphoric, mood-boosting effects when found in cannabis strains. While the research is limited, science has found promising evidence for valencene&rsquo;s health benefits and potential medical use.
A <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308289/" target="_blank" rel="noopener">study</a> that examined valencene and other terpenes found that the chemical reduced inflammatory response, potentially supporting the body&rsquo;s immune response. Another study supported these findings, observing that valencene displayed inhibitory <a href="https://pubmed.ncbi.nlm.nih.gov/21380805/" target="_blank" rel="noopener">anti-allergenic activity</a> in mice.&nbsp;
Additionally, valencene has promising potential as a skin protectant. <a href="https://pubmed.ncbi.nlm.nih.gov/27630735/" target="_blank" rel="noopener">Research</a> examining the application of valencene in skin conditions improved atopic <a href="https://leafwell.com/medical-conditions/eczema-psoriasis/">dermatitis</a>, reduced itching, soothed inflammatory response, and improved skin barrier protection.
Valencene also has indicated potential usefulness in preventing and treating different <a href="https://leafwell.com/medical-conditions/cancer/">cancers</a>. One <a href="https://pubmed.ncbi.nlm.nih.gov/26967731/" target="_blank" rel="noopener">study</a> found that valencene boosted skin protection and had a therapeutic impact on cells with melanoma. A more recent study observed that valencene improved <a href="https://pubmed.ncbi.nlm.nih.gov/28632185/" target="_blank" rel="noopener">the efficacy of Doxorubicin</a>, a drug commonly used in chemotherapy against more resistant cancer cells.
Finally, valencene&rsquo;s usefulness as an <a href="https://pubmed.ncbi.nlm.nih.gov/15962787/" target="_blank" rel="noopener">insecticide</a> can protect users against disease-carrying pests.
<h2 id="potential-risks-and-side-effects">Potential Risks and Side Effects</h2>
Current research reports hardly any potential risks and <a href="http://fragrancematerialsafetyresource.elsevier.com/sites/default/files/4630-07-3.pdf" target="_blank" rel="noopener">no known side effects</a> in consuming or topically using valencene. However, as with many essential oils, there is a slight risk of skin reactivity with topical use. Valencene is only toxic to insects, making it a helpful bug repellent.
<h2 id="cannabis-strains-high-in-valencene">Cannabis Strains High in Valencene</h2>
While sesquiterpene is less common in cannabis, many consumers mistakenly attribute to limonene the citrusy-sweet and fresh-cut-wood bouquet that belongs to valencene. A few <a href="https://leafwell.com/blog/choose-dose-cannabis-flower/">strains</a>/cultivars that more prominently feature valencene include:
<ul>
<li style="font-weight: 400;" aria-level="1">Tangie</li>
<li style="font-weight: 400;" aria-level="1">Agent Orange</li>
<li style="font-weight: 400;" aria-level="1">ACDC</li>
<li style="font-weight: 400;" aria-level="1">Sour Diesel</li>
<li style="font-weight: 400;" aria-level="1">Clementine</li>
<li style="font-weight: 400;" aria-level="1">Jillybean</li>
<li style="font-weight: 400;" aria-level="1">Gushers</li>
<li style="font-weight: 400;" aria-level="1">Jack Frost</li>
<li style="font-weight: 400;" aria-level="1">California Orange Bud</li>
</ul>
<h2 id="frequently-asked-questions">Frequently Asked Questions</h2>
<h3>What is valencene used for?</h3>
Valencene is a powerful insecticide, useful in pest-control products and topical bug sprays. The terpene is also prominent in many citrus-smelling beauty and personal care products, household cleaning products, and food items.
<h3>Which foods contain valencene?</h3>
Valencene is most commonly found in Valencia oranges, where the terpene gets its name. You can also find valencene in other citrus fruits, such as oranges, mangos, grapefruit, and tangerines, as well as the medicinal herb Chinese Bayberry.
<h3>What are the top uses for valencene?</h3>
The research is still preliminary, but valencene has shown promising therapeutic potential for anti-inflammatory, anti-allergic, skin protectant, and cancer preventive/treating properties.
Terpenes have a range of uses, and unlike cannabinoids, many of them do not necessarily target the endocannabinoid system (although some of them do, like <a href="https://leafwell.com/blog/what-is-beta-caryophyllene-peppery-terpene-cannabinoid/">beta-caryophyllene</a>). Terpenes like valencene may instead work on other receptor systems, like <a href="https://www.arca.fiocruz.br/bitstream/icict/46589/2/" target="_blank" rel="noopener">serotonin receptors</a>. This means that they can have health benefits of their own, and these benefits may even be increased by the addition of cannabinoids. More research into how cannabinoids, terpenes and <a href="https://leafwell.com/blog/flavonoids/">flavonoids</a> work together is much-needed.

four slices of orange with scattered leaves in a white bg

Content Writer

Shanti Ryle is a content marketer with more than half a decades’ experience writing about cannabis science and culture. Her work has been featured in Forbes, Weedmaps News/Marijuana.com, Wall Street Journal, and other publications.