Is It Safe to Mix LSD and Weed?
Article written by
Tina MagrabiSenior Content Writer
Content reviewed by
Dr. Lewis JasseyMedical Director - Pediatric Medicine
Mixing LSD and weed may not be safe for some people due to both drugs’ abilities to impair decision-making abilities. However, when used alone, a deadly overdose on either drug is more of a theoretical possibility than a practical one. Both cannabis and psychedelic drugs like LSD are relatively safe for those who aren’t prone to psychosis.
Learn more about LSD, its potential therapeutic benefits, and why it’s not a good idea to combine illegal recreational drugs with cannabis products.
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What Is LSD?
LSD, short for lysergic acid diethylamide, is a potent drug derived from the fungus that grows on rye and other grains. This potent psychedelic drug is also known as acid, dots, and mellow yellow. Despite the mellow yellow nickname, LSD is both colorless and odorless.
The drug is a powerful hallucinogen that can elicit positive and negative emotions, ranging from euphoria to paranoia.
LSD is illegal to use, possess, or sell in the United States. However, LSD has been studied for potential therapeutic benefits, particularly from the 1950s to the 1970s. Recently, there has been a resurgence of LSD research, as scientists have discovered that the drug could help treat alcoholism and numerous psychiatric conditions.
Uses, Effects, and How It Works
LSD is consumed orally, usually as microdots, sugar cubes, or as a liquid. Some people start to feel the effects of LSD as soon as 20 minutes after ingestion, and the effects generally peak by four hours and may linger for up to 12 hours.
Taking LSD is a pleasant experience for some people, who may experience colorful waking dreams and intense euphoria. Other people may negatively react to LSD and experience a “bad trip” of frightening hallucinations and severe mood swings.
LSD has these potent effects on the brain by interacting with serotonin receptors. Serotonin is a key chemical in mood regulation. Too much serotonin can be dangerous and even lead to death. But a balanced amount of serotonin can make people feel good.
In terms of addictiveness, LSD is not considered as dangerous as other drugs like opioids or heroin. But all drugs carry the potential for addiction and overdose, although people taking LSD are not likely to have a fatal overdose.
Potential Benefits and Risks of Mixing Cannabis and LSD
Mixing cannabis and LSD is a personal decision with associated benefits and risks.
Potential Benefits
The main reason people combine LSD use with marijuana is to feel good, and some users find that the two substances enhance each other’s effects and help them achieve a more potent high. Combining the two drugs at low doses may be safe, but it is not recommended due to the potential risks.
Some may engage in marijuana use at the end of their LSD trip to either elongate the tail-end of the trip or help them get to sleep. Both psychedelics and cannabis may also provide some amount of relief from cluster headaches if dosed appropriately.
Potential Risks
Combining LSD and marijuana may intensify not only the positive effects but also the negative effects of the two drugs. Here are some possible side effects that may increase when using LSD and weed together:
Perhaps the most dangerous potential side effect is impaired judgment. People under the influence of LSD and marijuana (or any combination of drugs) may be more likely to make poor decisions.
The Bottom Line
Some people may be able to safely combine LSD and marijuana, while others may experience negative effects, especially of a psychological nature. Ultimately, while it may be safe for some to combine the two in small doses, it’s wise to proceed with caution when mixing hallucinogenic drugs like LSD, psilocybin (“magic mushrooms“), etc., with other psychoactive drugs like marijuana.
Also, be aware of the laws where you live, as cannabis is not yet legal at the federal level in the United States and LSD is uniformly illegal.
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