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<p>There are no known interactions between Viagra (sildenafil) and cannabis, although <a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.4960250310" target="_blank" rel="noopener">some studies</a> suggest an increased risk of myocardial infarction (heart attack) if combined. Anecdotal reports also suggest that marijuana use may help <a href="https://leafwell.com/blog/does-weed-lower-sex-drive/">enhance sexual appetite</a> by reducing anxiety and increasing arousal, but mixed and inconclusive results exist in this area.</p>
<h2 id="what-is-viagra">What Is Viagra?</h2>
<p>Viagra is the brand name for the drug sildenafil. Other trade names include Aronix, Liberize, Nipatra, Revatio, and Grandipam. Sildenafil is taken by mouth or injection into a vein, with the typical onset time between 20 minutes and two hours. Viagra should not be taken by people on nitrates such as nitroglycerin (glycerin trinitrate), as this may result in a severe drop in blood pressure.</p>
<h2 id="uses-and-how-it-works">Uses and How It Works</h2>
<p>Viagra is most commonly prescribed for sexual dysfunction (in particular erectile dysfunction) in men and pulmonary arterial hypertension. Other medical uses include <a href="https://leafwell.com/medical-conditions/raynaud-syndrome-raynauds/">Raynaud&rsquo;s phenomenon</a> and high-altitude pulmonary edema. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes the breakdown of cGMP, which regulates blood flow and dilates blood vessels in the lungs. When it comes to sexual dysfunction, sexual arousal is required for sildenafil to work.</p>
<h2 id="potential-benefits-and-risks-of-mixing-cannabis-and-viagra">Potential Benefits and Risks of Mixing Cannabis and Viagra</h2>
<p>There are no interactions listed between cannabis and Viagra, positive, negative, or otherwise. However, more studies need to take place to know whether or not there is a drug-drug interaction between cannabis and sildenafil.</p>
<h3>Potential Benefits</h3>
<ul>
<li aria-level="1">Some side effects of sildenafil include <a href="https://leafwell.com/medical-conditions/loss-of-appetite/">loss of appetite</a>, <a href="https://leafwell.com/medical-conditions/migraine-headache/">headaches</a>, <a href="https://leafwell.com/medical-conditions/nausea-mitigation/">nausea, and vomiting</a>, which cannabis can help mitigate.</li>
<li aria-level="1">Cannabinoids and terpenes like <a href="https://leafwell.com/blog/what-is-thc-tetrahydrocannabinol/">tetrahydrocannabinol (THC)</a>, <a href="https://leafwell.com/blog/pinene/">pinene</a>, and <a href="https://leafwell.com/blog/eucalyptol/">eucalyptol</a> have <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720277/" target="_blank" rel="noopener">bronchodilatory</a> effects that could help ease breathing and improve blood flow.</li>
<li aria-level="1">Cannabinoids and terpenes like <a href="https://leafwell.com/blog/what-is-cbd/">cannabidiol (CBD)</a>, <a href="https://leafwell.com/blog/limonene/">limonene</a>, and <a href="https://leafwell.com/blog/linalool/">linalool </a>may help reduce <a href="https://leafwell.com/blog/medical-marijuana-and-anxiety/">anxiety</a> and improve mood, which in turn can help improve sexual function.</li>
</ul>
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<h3>Potential Risks</h3>
<ul>
<li aria-level="1">In the short term, cannabinoids like THC can increase heart rate, especially if inhaled. Sildenafil also increases heart rate, potentially increasing the chances of a heart attack.</li>
<li aria-level="1">In some instances, sildenafil can cause drowsiness, dry mouth, and dry eyes. Adding cannabis can increase the likelihood of these side effects.</li>
<li aria-level="1">Some studies have noted a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893937/" target="_blank" rel="noopener">relationship</a> between cannabis use and erectile dysfunction. Cannabis could therefore reduce the efficacy of sildenafil.</li>
</ul>
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<h2 id="the-bottom-line">The Bottom Line</h2>
<p>There is one case of a negative interaction between cannabis and sildenafil, where a combination of smoked marijuana and sildenafil caused a heart attack. Still, this case has not been repeated on any significant scale. Some studies have also noted a link between cannabis use and erectile dysfunction. Still, results are mixed, so there is no saying for sure whether or not cannabis will reduce the efficacy of sildenafil.</p>
<p>Sildenafil and cannabis work in different ways, and it is not out of the realm of possibility that cannabis may help reduce anxiety and improve sexual effect, function, and desire. Overall, we know very little about how the two drugs interact.</p>
<h2 id="frequently-asked-questions">Frequently Asked Questions</h2>
<h3>Does weed help with ED?</h3>
<p>Some studies suggest a <a href="https://www.medicalnewstoday.com/articles/317104" target="_blank" rel="noopener">connection</a> between erectile dysfunction (ED) and cannabis use. On the other hand, other studies have found an <a href="https://www.sciencedirect.com/science/article/abs/pii/S1743609517314170" target="_blank" rel="noopener">association</a> between cannabis use and increased frequency of sexual activity. <a href="https://pubmed.ncbi.nlm.nih.gov/31447385/" target="_blank" rel="noopener">Survey results</a> report that both men and women found that cannabis enhanced their experience and sex life. This suggests no definitive evidence that cannabis causes or helps with ED.</p>
<h3>Can you take Viagra if you smoke marijuana?</h3>
<p>Although one case of a heart attack occurs after simultaneous intake of sildenafil and cannabis, there seems to be little to no harm in healthy men using Viagra and cannabis simultaneously. Those with heart problems should proceed with caution, however.</p>
<h3>Does weed lower sperm count?</h3>
<p>&ldquo;<a href="https://pubmed.ncbi.nlm.nih.gov/30916627/" target="_blank" rel="noopener">Research supports</a> a role for cannabis in reducing sperm count and concentration,&rdquo; but these results are inconclusive for humans. Animal models have not been replicated in humans.</p>
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Head of Research and Education

Dipak Hemraj is a published author, grower, product maker, and Leafwell’s resident cannabis expert. From botany &amp; horticulture to culture and economics, he wishes to help educate the public on why cannabis is medicine (or a “pharmacy in a plant”) and how it can be used to treat a plethora of health problems. Dipak wants to unlock the power of the plant, and see if there are specific cannabinoid-terpene-flavonoid profiles suitable for different conditions.