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Can You Use Cannabis If You Take Fluvoxamine?

box of fluvoxamine tablets and herb

Taking fluvoxamine with cannabis is not recommended and may present dangerous side effects. Physical and mental health concerns are possible for people who combine the two drugs.

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What Is Fluvoxamine?

Fluvoxamine (brand name Luvox) belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). SSRIs address serotonin imbalances in the brain by increasing levels of this vital chemical. Balanced serotonin levels are associated with elevated mood and reduction of clinical depression in some individuals.

Uses and How It Works

Fluvoxamine works by increasing the amount of serotonin in the brain. It is FDA-approved for treating obsessive-compulsive disorder (OCD) in adults and may also be used to treat depression in some people.

Potential Benefits and Risks of Mixing Cannabis and Fluvoxamine

Pairing cannabis use with fluvoxamine may benefit some people and risk others. Discuss with your doctor whether combining cannabis and fluvoxamine is safe for you.

Potential Benefits

Few case reports or other research exist on the potential benefits of mixing weed with fluvoxamine. Some people may feel intensified sensations of relaxation, but such reports are anecdotal rather than evidence-based.

Potential Risks

Serotonin syndrome is one of the most serious risks associated with combining fluvoxamine and marijuana. This potentially fatal adverse reaction occurs when there is too much serotonin in the brain. Symptoms of serotonin syndrome include insomnia, confusion, dilated pupils, agitation, and loss of muscle coordination. Seek immediate medical attention if you experience these symptoms after taking fluvoxamine and cannabis. Fortunately, serotonin syndrome is a rare occurrence.

Other, more common adverse reactions of combining marijuana use with fluvoxamine include:

  • Panic attacks
  • Hallucinations
  • Irregular heartbeat
  • Nausea and vomiting
  • Diarrhea
  • Confusion and disorientation

Higher concentrations of cannabis and fluvoxamine are more likely to result in serious side effects. Still, any combination of the two drugs could trigger negative side effects in some people. Speak with your physician before combining cannabis with fluvoxamine or any other medication.

What to Do If You Need to Use Both Fluvoxamine and Marijuana

Only your doctor can determine whether you must use both fluvoxamine and marijuana. Consult your healthcare provider before combining the two medications to understand the potential risks and benefits.

The Bottom Line

Mixing SSRIs like fluvoxamine with cannabis is not recommended. The combination of drugs may be dangerous and result in severe mental and physical side effects. The potentially fatal serotonin syndrome is of particular concern for people using marijuana with fluvoxamine.

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Frequently Asked Questions

Can you mix CBD with fluvoxamine?

Since fluvoxamine is classified as an SSRI, mixing the drug with CBD is not advisable. Limited research is available on the adverse effects of combining CBD and fluvoxamine, but depression symptoms may increase in some people.

What can you not take with fluvoxamine?

Many prescription medications and over-the-counter drugs may interact negatively with fluvoxamine, such as St. John’s Wort, amphetamines, and pain and migraine medications. Speak with your doctor for a complete list of medications to avoid while taking fluvoxamine.