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<p>Hormones are neurotransmitters, and this means that they are chemical messengers which carry instructions to organs and tissues to carry out certain functions. Hormones are produced by various glands in our bodies, with the main hormone-producing gland being the pituitary gland.</p>
<p>Hormones are essential for a wide range of functions, such as growth, regulating blood sugar levels, the reproductive cycle, and mood. The network of glands that secrete these hormones is known as the endocrine system. <a href="https://leafwell.com/blog/endocannabinoid-system/" target="_blank" rel="noopener noreferrer">The endocannabinoid system (ECS)</a> can influence various receptor systems in every cell throughout our bodies.</p>
<p><a href="https://leafwell.com/blog/cannabis/">Cannabis</a> affects our hormones. As with many other medications, cannabis can make our bodies produce more hormones or less, depending on whether you are using <a href="https://leafwell.com/blog/how-does-cbd-work/">CBD</a> or <a href="https://leafwell.com/blog/what-is-thc-tetrahydrocannabinol/">THC</a>-heavy products. Sometimes, these hormone changes can have a positive medical impact, but sometimes the changes can be harmful. That&rsquo;s why it&rsquo;s crucial to understand how cannabis affects our hormones. We have touched on <a href="https://leafwell.com/blog/science-of-marijuana/" target="_blank" rel="noopener noreferrer">how cannabis affects various receptors throughout our bodies</a>.</p>
<p>We look at it in a little more detail in this article and remember, you can always ask the doctor during your consultation:</p>
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<h2 id="how-does-cannabis-affect-our-hormones">How Does Cannabis Affect Our Hormones?</h2>
<p>The ECS is linked to every receptor system in our bodies. Whether it&rsquo;s dopamine, serotonin, or opioid receptors, cannabinoids can &ldquo;talk&rdquo; to them and exert their influence in ways both subtle and overt. This includes our hormones and the endocrine system.</p>
<p>However, hormones are complicated, and we do not understand how cannabis and the endocannabinoid system interact with the endocrine system in any significant detail. We do know that cannabis interacts with it, though, as it affects the production of hormones like insulin, testosterone, and estrogen. The effects can be positive or negative.</p>
<p>To give a practical example, with estrogen-positive breast cancer, too much THC may be best avoided, as it can increase estrogen levels. CBD may be a better choice in such an instance, but we shouldn&rsquo;t necessarily get rid of THC entirely. This is because THC has many cancer-beating properties. Therefore, it is hugely important to match the THC:CBD ratio to the type of cancer you&rsquo;re treating. But it&rsquo;s complicated, and everybody is different. Here&rsquo;s what we know so far.</p>
<h2 id="cannabis-and-the-hypothalamus-pituitary-adrenal-hpa-axis">Cannabis and the Hypothalamus-Pituitary-Adrenal (HPA) Axis</h2>
<p>The HPA axis is perhaps one of the most well-known hormonal systems. The HPA is most often associated with flight-or-fight and stress. It is what produces cortisol. Cortisol helps control blood sugar levels, regulates metabolism, reduces inflammation, blood pressure via salt and water regulation, and assists memory formation.</p>
<p>However, having high cortisol levels produced by your body can be harmful. The negative feedback loops that prevent too much cortisol from being produced become less effective, which is a significant problem in post-traumatic stress disorder<a href="https://leafwell.com/blog/using-medical-marijuana-and-cbd-for-ptsd/" target="_blank" rel="noopener noreferrer">&nbsp;(PTSD)</a>. Both THC and CBD can reduce the amount of cortisol produced by lowering the body&rsquo;s response to stress.</p>
<p>Too much THC can increase cortisol levels after use, so it is essential to be careful with some medical conditions. Those who are just starting off using cannabis ought to microdose THC, as small doses can decrease anxiety, but large doses can increase anxiety. <a href="https://leafwell.com/blog/dosing-cannabis-medical-marijuana-10-key-things-to-consider/" target="_blank" rel="noopener noreferrer">Microdosing of THC is therefore extremely important to treat anxiety</a>.</p>
<p>Another hormone released by the HPA axis, adrenaline, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573050/" target="_blank" rel="noopener noreferrer">also lowered production by THC use</a>. This dampens the flight-or-fight response, and this can lead to slower reactions.</p>
<p><a href="https://www.jneurosci.org/content/27/26/6956" target="_blank" rel="noopener noreferrer">Serotonin is released by the HPA axis</a> and regulates mood, memory, sleep, digestion, and some muscular functions. Low serotonin levels can cause agitation, migraine, insomnia, and carbohydrate cravings, and high serotonin levels can cause agitation, confusion, and sedation. Keeping serotonin levels in balance is important for treating anxiety, depression, and PTSD.</p>
<p>THC helps treat anxiety, PTSD, and other associated disorders when used long-term. This is because the sustained release of cortisol blunts the stress response and decreases cortisol production.</p>
<p>Long-term THC use blunts the morning spike of cortisol, called Cortisol Awakening Response (CAR), which is one reason why you can feel the sleepy effects of THC upon awakening. This also makes using THC effective for the treatment of insomnia.</p>
<p>CBD can lower cortisol levels but is not necessarily as helpful as THC and CBN in treating insomnia.</p>
<h2 id="cannabis-and-the-hypothalamus-pituitary-thyroid-hpt-axis">Cannabis and the Hypothalamus-Pituitary-Thyroid (HPT) Axis</h2>
<p>The HPT axis is responsible for maintaining metabolic rate, heart, and digestive functions, muscle control, brain development, and bone health. The thyroid gland releases two main hormones: Triiodothyronine (T3) and Thyroxine (T4). The HPT axis is essential for controlling our bodies&rsquo; metabolism, including regulating the body&rsquo;s internal core temperature, weight, skin, and hair.</p>
<p><a href="https://link.springer.com/article/10.1007/BF01968699" target="_blank" rel="noopener noreferrer">THC can inhibit TSH</a>. Low circulating TSH levels can lead to symptoms associated with hyperthyroidism, such as fatigue, weight gain, and intolerance to the cold, decreased libido, depression, and an abnormal menstrual cycle.</p>
<p>You can diminish many of these negatives by using cannabinoids like CBD and low doses of <a href="https://leafwell.com/blog/what-is-tetrahydrocannabivarin-thcv-a-multi-purpose-appetite-suppressing-cannabinoid/" target="_blank" rel="noopener noreferrer">tetrahydrocannabivarin (THCV).</a></p>
<p>It is also worth remembering that reducing TSH levels is not necessarily always a negative. Those who have insomnia will want help getting to sleep. Cannabis users generally have a lower body mass index (BMI) compared to non-cannabis users, so weight gain is not usually an issue (although having a low BMI doesn&rsquo;t mean you aren&rsquo;t skinny fat, so <a href="https://leafwell.com/blog/working-out-high/" target="_blank" rel="noopener noreferrer">exercise is critical as well</a>). Many find that the stress-relieving properties of cannabis increase their libido. A mixture of THC and CBD at the correct dosage may help improve the mood, not cause depression. Some women also find that cannabis is beneficial for <a href="https://admin.leafwell.com/medical-conditions/pre-menstrual-syndrome-pms-medical-canabis/" target="_blank" rel="noopener noreferrer">PMS and menstrual cramps</a>, and there is very little evidence showing that it causes an abnormal menstrual cycle.</p>
<h2 id="cannabis-and-the-hypothalamus-pituitary-gonadal-hpg-axis-cannabis-and-the-menstrual-cycle">Cannabis and the Hypothalamus-Pituitary-Gonadal (HPG) Axis &ndash; Cannabis and the Menstrual Cycle</h2>
<p>The HPG axis plays a vital role in maintaining all tissues&rsquo; optimal functioning and health throughout the body. The HPG axis also oversees the body&rsquo;s functions related to reproductive health.</p>
<p>THC can reduce hormone levels in the HPG axis and lead to infertility in both men and women. THC can slow follicle maturation in women, which can lead to changes in the menstrual cycle. During ovulation, the body releases anandamide, and using THC can cause an excess of endocannabinoid production that disrupts the menstrual cycle.</p>
<p>Now, this may sound frightening to some, but for those suffering from premenstrual syndrome (PMS), using a <a href="https://leafwell.com/blog/why-does-the-1-to-1-cbd-to-thc-ratio-work-so-well/" target="_blank" rel="noopener noreferrer">combination of THC and CBD</a> may reduce pain, cramps, and <a href="https://admin.leafwell.com/medical-conditions/migraine-headache-medical-marijuana/" target="_blank" rel="noopener noreferrer">headaches/migraines</a>.</p>
<p><a href="https://pubmed.ncbi.nlm.nih.gov/6090909/" target="_blank" rel="noopener noreferrer">THC has been shown to decrease LH &amp; testosterone</a>, reduce sperm motility, and sperm&rsquo;s ability to achieve conception in men. Testosterone is also helpful for increasing muscle and bone mass and body hair growth, and insufficient testosterone can lead to bone and muscle mass loss.</p>
<p>Interestingly, research has identified that frequent cannabis users have <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863108/" target="_blank" rel="noopener noreferrer">lower prolactin levels in their blood plasma</a>. Prolactin inhibits FSH and GnRH, which is another way in which menstrual cycles and testosterone production are affected.</p>
<h2 id="cannabis-and-the-growth-hormone-gh-axis-aka-insulin-like-growth-factor-igf-1-axis">Cannabis and the Growth Hormone (GH) Axis, aka Insulin-like Growth Factor (IGF-1) Axis</h2>
<p>The GH/IGF axis produces the growth hormone somatotropin and insulin. Somatotropin stimulates growth, cell reproduction, cell regeneration, and boosting metabolism. Insulin regulates blood glucose levels by absorbing glucose into the liver, fat, and skeletal muscles. The GH axis is also involved in the regulation of brain development, including neurogenesis and neuroprotection.</p>
<p>Cannabis, particularly cannabinoids like CBD, <a href="https://leafwell.com/blog/what-is-cbg-cannabigerol-medicinal-benefits-use/">CBG</a>, and THCV, can help improve insulin sensitivity, allowing for sugar to be processed more readily. Cannabis can boost metabolism, which can prevent weight gain.</p>
<p>THC use when young can affect brain development, and cannabinoids like CBD and THCV have been beneficial for treating diabetes and neuropathic pain. THC, CBD, and THCV can be very useful in <a href="https://leafwell.com/blog/neuroplasticity-and-neurogenesis-is-cannabis-a-nootropic-that-boosts-the-brain/" target="_blank" rel="noopener noreferrer">promoting brain cell growth (neurogenesis)</a> for older people.</p>
<p>The ECS is intimately linked with all the hormonal axes, and it is with the GH axis that this link is perhaps most apparent.</p>
<h2 id="conclusion-the-positives-and-negatives-of-cannabis-use-on-hormones">Conclusion &ndash; The Positives and Negatives of Cannabis Use on Hormones</h2>
<p>Reading the above, it can be tempting to think that cannabis can harm hormonal systems, which is inaccurate, as EC dysregulation can cause hormonal dysregulation. This can lead to PMS, migraines, cancer, <a href="https://leafwell.com/blog/marijuana-and-diabetes/" target="_blank" rel="noopener noreferrer">diabetes</a>, PTSD, anxiety, depression, and many more health problems.</p>
<p>Also, much of the focus is on THC. THC binds to and affects CB1 receptors, which can cause changes in hormone levels. Other cannabinoids like CBD have less direct effects, and we know less about how CBD and other cannabinoids affect various hormones. It seems true that having a mixture of cannabinoids and <a href="https://leafwell.com/blog/terpenes/">terpenes</a> can help mitigate some of the adverse effects THC can have on hormones while also retaining some of its benefits.</p>


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Head of Research and Education

Dipak Hemraj is a published author, grower, product maker, and Leafwell’s resident cannabis expert. From botany &amp; horticulture to culture and economics, he wishes to help educate the public on why cannabis is medicine (or a “pharmacy in a plant”) and how it can be used to treat a plethora of health problems. Dipak wants to unlock the power of the plant, and see if there are specific cannabinoid-terpene-flavonoid profiles suitable for different conditions.